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Supercomputer simulations reveal how the molecular motor kinesin steers itself along tracks

Kinesin is a molecular motor responsible for hauling essential cargoes within cells by walking step by step along filamentous tracks known as microtubules. To move efficiently and avoid falling off, the motor's two feet must coordinate their stepping in a precise direction. Scientists have known that a connecting segment called the neck region is crucial for coordinating this motion. However, its exact three-dimensional structure and how it physically interacts with the microtubule track have remained a mystery because of the limitations of current imaging techniques.

Phys.orgPhys.org10 Sept

Water isotopes reveal early drought signals in Central Amazon rainfall

The historic droughts of 2023 and 2024 in the Amazon reduced river flows and altered the region's rainfall composition. Daily monitoring in Manaus, the capital of the Brazilian state of Amazonas, revealed these changes through the use of isotopes, which act as a kind of water "fingerprint." This method demonstrated how El Niño and warming in the North Atlantic affected the origin of moisture and precipitation dynamics.

Phys.orgPhys.org10 Sept

An unusual bacterium that penetrates and lives inside human cells may offer a new drug target

Research underway in the lab of Rebecca Alexander, a professor in Wake Forest University's Department of Chemistry, is shedding light on an unusual human bacterium, Mycoplasma penetrans. Alexander's work to understand how and why this unique pathogen acts as it does could one day lead to new classes of drugs that better target illnesses associated with this particular pathogen, as well as others that act similarly.

Phys.orgPhys.org10 Sept

First PLP-dependent enzyme that influences bacterial protein production discovered

Researchers from the Singapore-MIT Alliance for Research & Technology's (SMART) Antimicrobial Resistance (AMR) interdisciplinary research group, alongside collaborators from Massachusetts Institute of Technology (MIT), Nanyang Technological University (NTU Singapore), and institutions in the United States, Poland and France, have discovered aminovaleramididine synthetase (AvaS), the first identified pyridoxal phosphate (PLP)-dependent enzyme responsible for producing a chemical modification linked to how bacteria respond to metabolic stress.

Phys.orgPhys.org10 Sept

A cellular threshold can determine whether herpesvirus becomes active or lies dormant

During the COVID-19 pandemic, we wore masks and kept 2 meters (6.6 feet) apart in an effort to reduce the spread of the tiny droplets we release into the air with every breath, conversation or cough. The main goal was to reduce the number of virus particles—known as virions—to which we were exposed. For each virus, a person must be exposed to a minimum infectious dose to develop disease, and in many cases, the larger the dose, the more severe the illness.

Phys.orgPhys.org10 Sept

Ultrathin silicon structures can tune mid-IR light in billionths of a second

Light in the mid-infrared (mid-IR) portion of the electromagnetic spectrum plays a key role in modern sensing. Because molecules interact with this kind of light in specific ways, researchers use technologies like mid-IR spectroscopy to identify biological materials, drugs and pollutants. Mid-IR light can also serve as a carrier of information in free-space optical communications, where data are transmitted through the air without using cables or fibers. Better control of mid-IR light could therefore lead to more sensitive detectors and faster communications.

Phys.orgPhys.org10 Sept

Focus on biodiversity conservation may offer a less divisive path to climate action in Japan

If you want to drum up support for environmental action, putting climate change front and center may not always be the best strategy. A new study by Aya Takagi and Ryosuke Nakadai of Yokohama National University suggests that support for policies that emphasize biodiversity conservation, including conservation measures that also contribute to climate goals, may be less divided along cultural lines than measures explicitly associated with climate change.

Phys.orgPhys.org10 Sept